Baking Soda may fix cancer cell’s broken clock

A recent study┬áby Ludwig Cancer Research demonstrated that by restoring the pH of cancer cells by using baking soda (bicarbonate of soda) in the drinking water of mice, they restored the function of the cancer cells’ circadian clock. Only cancer cells which have this tick tock rhythm remain susceptible to cancer therapies.

This acid-mediated effect, the Ludwig researchers assert, can be reversed by sodium bicarbonate. When the researchers gave tumor-xenografted mice water that had been supplemented with sodium bicarbonate, the acidity of hypoxic patches in the tumors was neutralized. This reversal, the scientists say, was achieved by bringing mTOR1 and RHEB back into proximity with each other.

Acidification breaks the clock by moving constituent parts away from each other. See diagram above and explanation below. Bicarbonate of soda reverses this process.

Deprived of oxygen cancer cells survive by shifting their metabolism which creates a chain of consequences: increased acid production; dispersed perinuclear lysosomes to the periphery of the cell; separation of perinuclear-resident and peripheral-lysosome-resident signalling factors; signalling shift inhibits production of circadian clock components; collapse of circadian clock; and entry in to a quiescent cancer therapy resistant state. Bicarbonate of soda may break the first link in this chain by buffering against acidification, ultimately preserving the effectiveness of cancer therapy.